President Donald Trump has signed an executive order expanding federal research into psychedelic drugs and explore their use in controlled medical settings.

The order direct the Food and Drug Administration to issue new guidance for clinical trials involving substances such as psilocybin, ibogaine, LSD, and MDMA.

The podcast host Joe Rogan, who has long advocated for research into psychedelics, attended the signing ceremony.

Joe Rogan joins Trump in the Oval Office.

Let’s go. pic.twitter.com/HniutWdXeu

— Joe Rogan Podcast News (@joeroganhq) April 18, 2026

Such drugs are currently classified as Schedule I, meaning they are considered to have no accepted medical use and a high potential for abuse.

The administration believes in the potential role of these treatments in addressing post-traumatic stress disorder and other mental health conditions, particularly among military veterans.

The National Institutes of Health is also being tasked with supporting additional studies into the drugs.

President Trump is set to announce new efforts to boost research into psychedelics and potentially make the drugs available in controlled therapeutic environments, according to people who spoke on the condition of anonymity.https://t.co/WyMjovUHtd

— The Washington Post (@washingtonpost) April 18, 2026

Health Secretary Robert F. Kennedy Jr. long advocated for expanding research into psychedelics, arguing they could play a role in treating depression and other conditions.

FDA’s war on public health is about to end. This includes its aggressive suppression of psychedelics, peptides, stem cells, raw milk, hyperbaric therapies, chelating compounds, ivermectin, hydroxychloroquine, vitamins, clean foods, sunshine, exercise, nutraceuticals and anything…

— Robert F. Kennedy Jr (@RobertKennedyJr) October 25, 2024

Ibogaine, one of the substances under consideration, has been linked to potential heart risks.

Former Texas Governor Rick Perry has previously claimed the effects of ibogaine treatment had fantastic potential in treating a variety of health issues.

Rick Perry & W. Bryan Hubbard on the ‘Miraculous’ Clinical Trial Results Seen w/ Plant-Based Psychoactive Compound Ibogaine

“The results of that study are nothing short of miraculous when it comes to the way in which Ibogaine has been revealed to have significant… pic.twitter.com/0tbliNE8kD

— Chief Nerd (@TheChiefNerd) January 2, 2025

Researchers and industry figures say restrictions have stunted progress in studying potential medical applications and breakthrough treatments.

However, some experts have warned that widespread use remains years away and would require extensive clinical validation.

Psychedelics such as psilocybin, LSD, and MDMA still remain illegal under federal law and are restricted to approved research.

Some states have begun loosening restrictions, with Oregon and Colorado allowing supervised psilocybin use and New Mexico moving toward a medical program.

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